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MGMT 蛋白

This Recombinant MGMT protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7939403
发货至: 中国
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Quick Overview for MGMT 蛋白 (ABIN7939403)

抗原

See all MGMT 蛋白
MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

应用范围

Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)
  • 原理

    Recombinant MGMT protein
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    Product
    表达系统
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    价格从 145,985.55 ¥

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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Recombinant MGMT protein is supplied in 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 10 % glycerol and 0.5 mM TCEP.

    注意事项

    Avoid repeated freeze/thaw cycles,keep on ice when not in storage

    储存条件

    -80 °C

    储存方法

    Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
  • 抗原

    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))

    别名

    MGMT

    背景

    Protein Background: MGMT(Methylated-DNA--protein-cysteine methyltransferase) Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

    Short Description: Recombinant MGMT protein that includes full length of human MGMT protein (accession number NP_002403.3) was expressed was expressed in E. coli cells with an N-terminal GST tag. The molecular weight of the protein is 48.48 kDa.

    Aliases: O-6-Methylguanine-DNA Methyltransferase

    途径

    DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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