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MGMT Protein (His tag)

MGMT 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % as determined by reducing SDS-PAGE.
产品编号 ABIN7318122
发货至: 中国
  • 抗原 See all MGMT 蛋白
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    蛋白类型
    Recombinant
    宿主
    • 7
    • 2
    • 1
    • 1
    资源
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This MGMT protein is labelled with His tag.
    原理
    Recombinant Human MGMT Protein (His Tag)
    序列
    Met 1-Asn207
    产品特性
    Recombinant Human Methylated-DNA--protein-cysteine methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Asn207 is expressed with a 6His tag at the N-terminus.
    纯度
    > 90 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product MGMT 蛋白
  • 限制
    仅限研究用
  • 状态
    Frozen, Liquid
    缓冲液
    Supplied as a 0.2 μm filtered solution of 20 mMTrisHCl,1 mM EDTA, pH 8.0 .
    储存条件
    -20 °C
    储存方法
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    别名
    MGMT (MGMT 产品)
    别名
    AGT Protein, AI267024 Protein, Agat Protein, O-6-methylguanine-DNA methyltransferase Protein, MGMT Protein, Mgmt Protein
    背景

    Background: MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

    Synonym: Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase,O-6-methylguanine-DNA-alkyltransferase, MGMT

    分子量
    23.8 kDa
    UniProt
    P16455
    途径
    DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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