MAP2K7 蛋白
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北京 101111
Quick Overview for MAP2K7 蛋白 (ABIN7939337)
抗原
See all MAP2K7 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant MAP2K7 (MEK7) protein
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Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 1-426) protein (GST tag)
MAP2K7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) protein (Myc-DYKDDDDK Tag)MAP2K7 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) proteinMAP2K7 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) proteinMAP2K7 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MAP2K7 (MEK7) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
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别名
- MAP2K7
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背景
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Protein Background: MAP2K7 (Dual specificity mitogen-activated protein kinase kinase 7), also known as JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4 and SAPKK4. MAP2K7 is a dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE.
Short Description: Recombinant MAP2K7 (MEK7) protein was expressed in a baculovirus expression system as the full length protein (accession number NP_660186.1) with an N-terminal FLAG tag. The molecular weight of the protein is 48.77 kDa.
Aliases: Mitogen Activated Protein Kinase Kinase 7, MKK7, Kinase 7, JNKK2, MAPLL7, MEK, MEK7, MKK7, PRKMK7, SAPKK-4
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途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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