eIF4EBP1 蛋白
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北京 101111
Quick Overview for eIF4EBP1 蛋白 (ABIN7938835)
抗原
See all eIF4EBP1 (EIF4EBP1) 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant EIF4EBP1 protein
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Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (GST tag)
EIF4EBP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (His tag)EIF4EBP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS
Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (His tag)EIF4EBP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EIF4EBP1 protein is supplied in 25 mM Tris pH 7.4, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
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别名
- EIF4EBP1
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背景
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Protein Background: EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1 ) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Short Description: Recombinant EIF4EBP1 protein was expressed in E.coli as the full length protein (accession number NP_004086.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 14.51 kDa.
Aliases: Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1
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途径
- MAPK Pathway, PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling
抗原
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