EPH Receptor B2 Protein (EPHB2) (AA 570-987)
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Quick Overview for EPH Receptor B2 Protein (EPHB2) (AA 570-987) (ABIN7938803)
抗原
See all EPH Receptor B2 (EPHB2) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 570-987
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原理
- Recombinant EPHB2 (570-987) protein
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EPH Receptor B2 (EPHB2) (AA 19-542) (Active) protein (His tag)
EPHB2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B2 (EPHB2) (AA 19-543) (Active) protein (His tag)EPHB2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B2 (EPHB2) (AA 570-987) (Active) protein (GST tag,His tag)EPHB2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
EPH Receptor B2 (EPHB2) (AA 19-543) protein (His tag)EPHB2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
EPH Receptor B2 (EPHB2) (AA 19-543) (Active) protein (His tag)EPHB2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS, AcA Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EPHB2 (570-987) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- EPH Receptor B2 (EPHB2)
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别名
- EPHB2
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背景
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Protein Background: EPHB2 is a receptor tyrosine kinase,has a prototypical RTK topology including an N-terminal multidomain extracellular region, a membrane spanning region, and an intracellular region.EPHB2 binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation.
Short Description: Recombinant EPHB2 (570-987) protein that includes amino acids 570-987 of human EPHB2 protein (accession number NP_004433.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.65 kDa.
Aliases: EPH receptor B2, EPHT3, HEK5, DRT, ERK, Hek5, Tyro5
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途径
- RTK signaling, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins
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