EPH Receptor B2 Protein (EPHB2) (AA 570-987) (His-GST)
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Quick Overview for EPH Receptor B2 Protein (EPHB2) (AA 570-987) (His-GST) (ABIN7317086)
抗原
See all EPH Receptor B2 (EPHB2) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 570-987
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标记
- This EPH Receptor B2 protein is labelled with His-GST.
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原理
- Recombinant Human EphB2 Protein (aa 570-987, His &GST Tag)
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序列
- Gly570-Val987
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产品特性
- A DNA sequence encoding the human EPHB2 (P29323-3) (Gly570-Val987) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 120 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
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EPH Receptor B2 (EPHB2) (AA 19-542) (Active) protein (His tag)
EPHB2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B2 (EPHB2) (AA 19-543) (Active) protein (His tag)EPHB2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B2 (EPHB2) (AA 19-543) protein (His tag)EPHB2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
EPH Receptor B2 (EPHB2) (AA 19-543) (Active) protein (His tag)EPHB2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS, AcA Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 3 mM DTT, 10 % glycerol
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- EPH Receptor B2 (EPHB2)
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别名
- EphB2
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背景
- CAPB,DRT,EK5,EPHB2,EPHT3,ERK,Ephrin type-B receptor 2,Hek5,PCBC,Tyro5,Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
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分子量
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Calculated MW: 75.2 kDa
Observed MW: 65 kDa
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基因ID
- 2048
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UniProt
- P29323
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途径
- RTK signaling, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins
抗原
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