EPH Receptor A4 Protein (EPHA4) (AA 570-986)
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Quick Overview for EPH Receptor A4 Protein (EPHA4) (AA 570-986) (ABIN7938798)
抗原
See all EPH Receptor A4 (EPHA4) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 570-986
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原理
- Recombinant EPHA4 (570-986) protein
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EPH Receptor A4 (EPHA4) (AA 20-547) (Active) protein (His tag)
EPHA4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A4 (EPHA4) (AA 1-986) protein (GST tag)EPHA4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (AA 887-986) protein (GST tag)EPHA4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (AA 1-105) protein (GST tag)EPHA4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
EPH Receptor A4 (EPHA4) (Active) protein (His tag)EPHA4 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
EPH Receptor A4 (EPHA4) (AA 570-986) (Active) protein (GST tag,His tag)EPHA4 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 99 % as determined by reducing SDS-PAGE. Active
EPH Receptor A4 (EPHA4) (Active) protein (Fc Tag)EPHA4 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
EPH Receptor A4 (EPHA4) (AA 20-547) protein (His tag)EPHA4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
EPH Receptor A4 (EPHA4) (AA 20-547) protein (His tag)EPHA4 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % SDS
EPH Receptor A4 (EPHA4) (AA 20-547) (Active) protein (His tag)EPHA4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EPHA4 (570-986) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- EPH Receptor A4 (EPHA4)
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别名
- EPHA4
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背景
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Protein Background: EPHA4 (Ephrin type-A receptor 4) is a receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation.
Short Description: Recombinant EPHA4 (570-986) protein that includes amino acids 570-986 of human EPHA4 protein (accession number NP_001291465.1) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.46 kDa.
Aliases: Ephrin type-A receptor 4, EPH Receptor A4, HEK8, TYRO1, Tyrosine-Protein Kinase Receptor SEK, EK8
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途径
- RTK signaling
抗原
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