EPH Receptor A2 Protein (EPHA2) (AA 561-976)
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Quick Overview for EPH Receptor A2 Protein (EPHA2) (AA 561-976) (ABIN7938796)
抗原
See all EPH Receptor A2 (EPHA2) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 561-976
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原理
- Recombinant EPHA2 (561-976) protein
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EPH Receptor A2 (EPHA2) (AA 24-534) protein (His tag)
EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
EPH Receptor A2 (EPHA2) (AA 24-534) (Active) protein (His-Avi Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 24-534) (Active) protein (hFc Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 24-537) (Active) protein (His tag)EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 26-538) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 204-326) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 1-976) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
EPH Receptor A2 (EPHA2) (AA 585-976) (Active) protein (GST tag,His tag)EPHA2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
EPH Receptor A2 (EPHA2) (AA 26-535) protein (His tag)EPHA2 宿主: 小鼠 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EPHA2 (561-976) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- EPH Receptor A2 (EPHA2)
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别名
- EPHA2
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背景
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Protein Background: EPHA2(Ephrin type-A receptor 2) is a receptor tyrosine kinase which binds promiscuously membranebound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/ EFNA1 regulates migration, integrin-mediated adhesion, proliferation, and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
Short Description: Recombinant EPHA2 (561-976) protein that includes amino acids 561-976 of human EPHA2 protein (accession number NP_004422.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.50 kDa.
Aliases: Ephrin type-A receptor 2, EPH receptor A2, ECK, CTRCT6, EphA2, ARCC2, CTPP1, CTPA
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途径
- RTK signaling
抗原
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