EPH Receptor A2 Protein (EPHA2) (AA 585-976) (His-GST)
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Quick Overview for EPH Receptor A2 Protein (EPHA2) (AA 585-976) (His-GST) (ABIN7317048)
抗原
See all EPH Receptor A2 (EPHA2) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 585-976
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标记
- This EPH Receptor A2 protein is labelled with His-GST.
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原理
- Recombinant Human EphA2 Protein (aa 585-976, His & GST Tag)
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序列
- Leu 585-Ile 976
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产品特性
- A DNA sequence encoding the human EPHA2 (P29317) (Leu585-Ile976) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 50 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
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EPH Receptor A2 (EPHA2) (AA 24-534) protein (His tag)
EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
EPH Receptor A2 (EPHA2) (AA 24-534) (Active) protein (His-Avi Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 24-534) (Active) protein (hFc Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 24-537) (Active) protein (His tag)EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 26-538) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor A2 (EPHA2) (AA 204-326) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 1-976) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 26-535) protein (His tag)EPHA2 宿主: 小鼠 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
EPH Receptor A2 (EPHA2) (AA 26-535) protein (His tag)EPHA2 宿主: 小鼠 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
EPH Receptor A2 (EPHA2) (AA 27-537) (Active) protein (His tag)EPHA2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % SDS, AcA Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH 8.5, 10 % glycerol
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- EPH Receptor A2 (EPHA2)
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别名
- EphA2
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背景
- ARCC2,CTPA,CTPP1,CTRCT6,ECK,EPHA2,Ephrin type-A receptor 2,Epithelial cell kinase,Tyrosine-protein kinase receptor ECK,Eph receptor A2 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.
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分子量
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Calculated MW: 72.1 kDa
Observed MW: 62 kDa
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基因ID
- 1969
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UniProt
- P29317
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途径
- RTK signaling
抗原
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