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IL-18 蛋白

This Recombinant IL-18 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7849705
发货至: 中国
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Quick Overview for IL-18 蛋白 (ABIN7849705)

抗原

See all IL-18 (IL18) 蛋白
IL-18 (IL18) (Interleukin 18 (IL18))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

应用范围

SDS-PAGE (SDS)

纯度

>95 % by SDS-PAGE
  • 原理

    Recombinant Human IL-18 Protein

    过滤

    0.2 μm filtered

    内毒素水平

    <0.01 EU/μg by LAL test
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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration<100 μg/mL.)

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,5 % Sucrose,0.1 % Tween80, pH 7.4.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
  • 抗原

    IL-18 (IL18) (Interleukin 18 (IL18))

    别名

    IL-18

    背景

    Synonyms: IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18

    Description: Recombinant human IL-18 is produced by the E.coli system, with the target gene encoding Tyr37-Asp193 expressed.

    Background: Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene.[The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells.Originally, IL-18 production was recognized in Kupffer cells, and liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells.IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases.

    UniProt

    Q14116

    途径

    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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