IL-18 Protein (AA 37-193) (Fc Tag)
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Quick Overview for IL-18 Protein (AA 37-193) (Fc Tag) (ABIN6964366)
抗原
See all IL-18 (IL18) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 37-193
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标记
- This IL-18 protein is labelled with Fc Tag.
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原理
- Recombinant Human IL18 with C-terminal human Fc tag
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特异性
- IL18(Tyr37-Asp193) hFc(Glu99-Ala330)
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产品特性
- Extracellular Domain Protein
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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Interleukin 18 (IL18) (AA 37-193) (Active) protein (Biotin)
IL18 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Interleukin 18 (IL18) (AA 37-193) protein (His-IF2DI Tag)IL18 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 18 (IL18) (AA 1-193) protein (GST tag)IL18 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 18 (IL18) protein (His tag)IL18 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 18 (IL18) protein (GST tag)IL18 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % as determined by reducing SDS-PAGE.
Interleukin 18 (IL18) (AA 36-192) protein (His tag)IL18 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Interleukin 18 (IL18) (AA 37-193) protein (mFc Tag)IL18 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Interleukin 18 (IL18) (AA 36-192) proteinIL18 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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应用备注
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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说明
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please see Certificate of Analysis for specific instructions of reconstitution.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- IL-18 (IL18) (Interleukin 18 (IL18))
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别名
- IL18
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背景
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IGIF,IL-1g,IL-18,IL1F4
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020] -
分子量
- predicted molecular mass of 44.3 kDa after removal of the signal peptide.The apparent molecular mass of IL18-hFc is 35-55 kDa due to glycosylation.
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UniProt
- Q14116
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途径
- Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
抗原
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