IGFBP4 蛋白
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北京 101111
Quick Overview for IGFBP4 蛋白 (ABIN7849677)
抗原
See all IGFBP4 蛋白蛋白类型
宿主
资源
应用范围
纯度
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原理
- Recombinant Human IGFBP4 Protein
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Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) protein (GST tag)
IGFBP4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) (Active) protein (His tag)IGFBP4 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) protein (His-IF2DI Tag)IGFBP4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 20 mM Tris-HCl, 300 mM NaCl, pH 9.0 with 0.2 % SKL as the preservative.
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储存条件
- 4 °C,-20 °C
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储存方法
- Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
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别名
- IGFBP4
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背景
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Synonyms: Insulin-like growth factor-binding protein 4, IGFBP4, IBP-4, IGF-binding protein 4, IGFBP-4, IBP4
Description: Recombinant human Insulin Like Growth Factor Binding 4 protein with molecular weight of 31.7 kDa.
Background: Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.IGFBP4 maternal blood concentrations were lower during pregnancy than during non-pregnant cycles and synchronized control cycles. It can be speculated that the lower IGFBP4 in maternal blood may result in an increase of free IGF1 for local action. IGFBP4 downregulation in GCTs compared to MSCs. Overexpression of UCHL1 and IGFBP4 by stable transfection of GCTSC did not influence cell viability, proliferation, migration and chemosensitivity compared to parental cells. However, colony-formation was significantly decreased suggesting that rescue of UCHL1 and IFGBP4 suppresses clonogenicity of GCT stromal cells. Epigenetic silencing of UCHL1 and IGFBP4 in GCTs might thus be a crucial event during the malignant transformation of MSCs in the context of GCT development and represent promising targets for the development of new diagnostic and therapeutic strategies.
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途径
- WNT signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
抗原
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