PD-L1 Protein (His tag)
Quick Overview for PD-L1 Protein (His tag) (ABIN7668351)
抗原
See all PD-L1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This PD-L1 protein is labelled with His tag.
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原理
- Recombinant Human PD-L1/B7-H1/CD274 protein (His tag)
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序列
- Phe19-Thr 239
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纯化方法
- > 95 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 10 EU/mg of the protein as determined by the LAL method.
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CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)
PD-L1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc Tag)PD-L1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)PD-L1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD274 (PD-L1) (AA 19-238) protein (Fc Tag)PD-L1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag,Biotin)PD-L1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag,Biotin)PD-L1 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) (Active) protein (His tag,AVI tag,Biotin)PD-L1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD274 (PD-L1) (AA 18-238) protein (His-DYKDDDDK-Strep II Tag)PD-L1 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD274 (PD-L1) (AA 19-238) (Active) protein (Fc Tag)PD-L1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- PD-L1 (CD274 (PD-L1))
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别名
- PD-L1,B7-H1,CD274
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背景
- CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.,B7 homolog 1,B7-H1,B7H1,CD274,PD-L1,PDCD1 ligand 1,PDCD1L1,PDCD1LG1,PDL1,Programmed Cell Death 1 Ligand 1,Programmed death ligand 1
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分子量
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calculated_mw: 24.1 kDa
observed_mw: 31 kDa
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UniProt
- Q9NZQ7
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途径
- Cancer Immune Checkpoints
抗原
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