Thrombospondin 1 Protein (THBS1) (AA 19-1170) (Fc Tag)
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- 抗原 See all Thrombospondin 1 (THBS1) 蛋白
- Thrombospondin 1 (THBS1)
- 蛋白类型
- Recombinant
- 产品特性
- AA 19-1170
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Thrombospondin 1 protein is labelled with Fc Tag.
- 原理
- Thrombospondin-1 (human):Fc (human) (rec.)
- 交叉反应
- 人
- 产品特性
- The extracellular domain of human thrombospondin-1 (aa 19-1170) is fused to the N-terminus of the Fc region of human IgG1.
- 纯度
- >98 % (SDS-PAGE)
- 过滤
- Sterile filtered
- 内毒素水平
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product THBS1 蛋白
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Thrombospondin 1 (THBS1) (AA 19-350) protein (His tag)
THBS1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombospondin 1 (THBS1) (AA 19-344) protein (His tag)THBS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombospondin 1 (THBS1) (AA 19-265) protein (His tag)THBS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- Thrombospondin 1 (THBS1)
- 别名
- Thrombospondin-1 (THBS1 产品)
- 背景
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TSP1
Thrombospondin-1 (TSP1) is a 150-180 kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the thrombospondin family, TSP-2 is also homotrimeric, while TSP-3, -4, and -5/COMP are homopentameric. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal laminin G-like globular domain, an extended central region with one VWFC domain, 3 TSP type-1 domains, 2 EGF-like domains, and 8 TSP type-3 domains and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive and anti-thrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGFR-2 signaling on vascular endothelial cells (EC) and destabilizes adhesive contacts between EC. TSP-1's actions on vascular smooth muscle cells support arterial tone and blood pressure in the presence of vasodilatory stimulation. It is released from activated platelets and enhances platelet aggregation and adhesion. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP). TSP-1 dampens adaptive immune responses by inducing the differentiation of regulatory T cells and inhibiting TCR signaling. In the nervous system, it promotes excitatory synapse formation and supports the integration of neural progenitor cells into the olfactory bulb. In addition, TSP-1 is released by apoptotic cells and promotes macrophage-mediated debris clearance.
- NCBI登录号
- NP_003237
- 途径
- Autophagy
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