Dematin Protein (AA 1-405) (His tag)
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北京 101111
Quick Overview for Dematin Protein (AA 1-405) (His tag) (ABIN7565230)
抗原
See all Dematin (EPB49) 蛋白蛋白类型
宿主
资源
纯度
质量等级
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产品特性
- AA 1-405
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标记
- This Dematin protein is labelled with His tag.
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原理
- Predefined custom protein recombinant Dmtn Protein expressed in mammalian cells.
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序列
- MERLQKQPLT SPGSVSSSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD KAILDIERPD LMIYEPHFTY SLLEHVELPR SRECSLSPKS TSPPPSPEVW AESRTLGIIS QASTPRTTGT PRTSLPHFHH PETTRPDSNI YKKPPIYKQR ESVGGSPQSK HLIEDLIIES SKFPAAQPPD PNQPAKIETD YWPCPPSLAV VETEWRKRKA SRKGAEEEEE EEDDDSEEEI KAIRERQKEE LSKVTSNLGK MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HSGTSKSSSL PSYGRTTLSR LQSTEFSPSG SEAGSPGLQN GEGQRGRMDR GNSLPCVLEQ KIYPYEMLVV TNKGRTKLPP GVDRMRLERH LSAEDFSRVF AMSPEEFGKL ALWKRNELKK KASLF Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 1-405) protein (His tag)
custom-made EPB49 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 1-383) protein (GST tag)EPB49 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)EPB49 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)EPB49 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)EPB49 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
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别名
- Dmtn
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背景
- Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9),FUNCTION: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts, acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:12011427, ECO:0000269|PubMed:18505823, ECO:0000269|PubMed:23060452}.
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分子量
- 45.5 kDa
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UniProt
- Q9WV69
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AlphaFold
- Q9WV69
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途径
- Regulation of Actin Filament Polymerization
抗原
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