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Dematin Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

This Recombinant Dematin protein is expressed in HEK-293 Cells.
产品编号 ABIN2719379
发货至: 中国
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Quick Overview for Dematin Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag) (ABIN2719379)

抗原

See all Dematin (EPB49) 蛋白
Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))

蛋白类型

Recombinant

宿主

  • 6
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资源

  • 4
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HEK-293 Cells

应用范围

Antibody Production (AbP), Standard (STD)

纯度

> 80 % as determined by SDS-PAGE and Coomassie blue staining
  • 产品特性

    Transcript Variant 3

    标记

    This Dematin protein is labelled with Myc-DYKDDDDK Tag.

    产品特性

    • Recombinant human Dematin (transcript variant 3) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 127,054.94 ¥

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  • 应用备注

    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays

    说明

    The tag is located at the C-terminal.

    限制

    仅限研究用
  • 浓度

    50 μg/mL

    缓冲液

    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

    储存条件

    -80 °C

    储存方法

    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • 抗原

    Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))

    别名

    Dematin

    背景

    The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3&apos coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

    分子量

    45.3 kDa

    NCBI登录号

    NP_001107608

    途径

    Regulation of Actin Filament Polymerization
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