NOXA Protein (AA 1-103) (His tag)
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北京 101111
Quick Overview for NOXA Protein (AA 1-103) (His tag) (ABIN7561692)
抗原
See all NOXA (PMAIP1) 蛋白蛋白类型
宿主
资源
纯度
质量等级
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产品特性
- AA 1-103
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标记
- This NOXA protein is labelled with His tag.
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原理
- Predefined custom protein recombinant Pmaip1 Protein expressed in mammalian cells.
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序列
- MPGRKARRNA PVNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITVVLAQM PGKSQKSRMR SPSPTRVPAD LKDECAQLRR IGDKVNLRQK LLNLISKLFN LVT Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-54) protein (Fc Tag)
custom-made PMAIP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-136) protein (GST tag)PMAIP1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) protein (Myc-DYKDDDDK Tag)PMAIP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
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别名
- Pmaip1
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背景
- Phorbol-12-myristate-13-acetate-induced protein 1 (Protein Noxa),FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15901672, ECO:0000269|PubMed:16822983, ECO:0000269|PubMed:17389404}.
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分子量
- 11.6 kDa
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UniProt
- Q9JM54
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AlphaFold
- Q9JM54
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途径
- p53 Pathway, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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