KLRC1 Protein (AA 1-233) (His tag)
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北京 101111
Quick Overview for KLRC1 Protein (AA 1-233) (His tag) (ABIN7549763)
抗原
See all KLRC1 蛋白蛋白类型
宿主
资源
纯度
质量等级
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产品特性
- AA 1-233
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标记
- This KLRC1 protein is labelled with His tag.
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原理
- Predefined custom protein recombinant KLRC1 Protein expressed in mammalian cells.
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序列
- MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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想要此Protein的其他选项吗？
!探索我们的目录蛋白和定制蛋白服务选项！Product表达系统ConjugateOriginPrice表达系统 HEK-293 CellsConjugate Biotin,His-Avi TagOrigin HumanPrice 6,261.95 ¥表达系统 HEK-293 CellsConjugate His-Avi TagOrigin HumanPrice 3,956.76 ¥表达系统 HEK-293 CellsConjugate hFc TagOrigin HumanPrice 3,956.76 ¥表达系统 HEK-293 CellsConjugate Fc TagOrigin HumanPrice 7,574.17 ¥表达系统 Wheat germConjugate GST tagOrigin HumanPrice 5,782.24 ¥表达系统 Baculovirus infected Insect CellsConjugate His tagOrigin HumanPrice 15,253.89 ¥表达系统 Human CellsConjugate His tagOrigin HumanPrice 1,886.64 ¥表达系统 Mammalian CellsConjugate His tagOrigin HumanPrice 2,380.07 ¥表达系统 Wheat germConjugateOrigin HumanPrice 8,510.26 ¥表达系统 HEK-293 CellsConjugate His tagOrigin HumanPrice 4,475.67 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 100-233) (Active) protein (Biotin,His-Avi Tag)
KLRC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 100-233) (Active) protein (His-Avi Tag)KLRC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 100-219) (Active) protein (hFc Tag)KLRC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 99-330) protein (Fc Tag)KLRC1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 1-233) protein (GST tag)KLRC1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) protein (His tag)KLRC1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) (AA 94-233) protein (His tag)KLRC1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))
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别名
- KLRC1
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背景
- NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a),FUNCTION: Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220, PubMed:37264229). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:30860984, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206, ECO:0000269|PubMed:9486650}., FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. Recognizes HLA-E in complex with human cytomegalovirus UL40-derived peptide (VMAPRTLIL) and inhibits NK cell cytotoxicity. {ECO:0000269|PubMed:10669413, ECO:0000269|PubMed:23335510}., FUNCTION: (Microbial infection) May recognize HLA-E in complex with HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}., FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32203188, PubMed:32859121). On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32203188, ECO:0000269|PubMed:32859121}.
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分子量
- 26.3 kDa
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UniProt
- P26715
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AlphaFold
- P26715
抗原
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