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PCNA 蛋白

PCNA 宿主: 人 宿主: HEK-293 Cells Recombinant > 92 % by SDS-PAGE.
产品编号 ABIN7536214
发货至: 中国
  • 抗原 See all PCNA 蛋白
    PCNA (Proliferating Cell Nuclear Antigen (PCNA))
    蛋白类型
    Recombinant
    宿主
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    资源
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    HEK-293 Cells
    原理
    Recombinant Human Proliferating cell nuclear antigen/PCNA Protein
    序列
    FEARLVQGSI LKKVLEALKD LINEACWDIS SSGVNLQSMD SSHVSLVQLT LRSEGFDTYR CDRNLAMGVN LTSMSKILKC AGNEDIITLR AEDNADTLAL VFEAPNQEKV SDYEMKLMDL DVEQLGIPEQ EYSCVVKMPS GEFARICRDL SHIGDAVVIS CAKDGVKFSA SGELGNGNIK LSQTSNVDKE EEAVTIEMNE PVQLTFALRY LNFFTKATPL SSTVTLSMSA DVPLVVEYKI ADMGHLKYYL APKIEDEEGS
    特异性
    Phe2-Ser261
    纯度
    > 92 % by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    <0.1EU/μg
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    Discover our top product PCNA 蛋白
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    Product
    表达系统
    Conjugate
    Origin
    价格从
    表达系统 HEK-293 Cells
    Conjugate His tag
    Origin Human
    价格从 106,314.67 ¥
    表达系统 Cell-free protein synthesis (CFPS)
    Conjugate Strep Tag
    Origin Human
    价格从 172,528.32 ¥

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  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    浓度
    1.6 mg/mL
    缓冲液
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    储存条件
    -20 °C,-80 °C
    储存方法
    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • 抗原
    PCNA (Proliferating Cell Nuclear Antigen (PCNA))
    别名
    Proliferating cell nuclear antigen/PCNA (PCNA 产品)
    背景

    Description: Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replicating forks during S phase and (ii) a soluble form in quiescent cells in G1 and G2 phases. PCNA forms a toroidal trimer in S phase with replication factor-C (RF-C) and DNA in an ATP-dependent manner and enables the loading of DNA polymerase delta and epsilon onto the complex. The close association of PCNA with kinase complexes involved in cell cycle machinery indicates that PCNA has a regulatory role in cell cycle progression. PCNA also participates in the processing of branched intermediates that arise during the lagging strand DNA synthesis.

    Name: ATLD2,Proliferating cell nuclear antigen,PCNA

    基因ID
    5111
    UniProt
    P12004
    途径
    Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
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