EPH Receptor A2 Protein (EPHA2)
Quick Overview for EPH Receptor A2 Protein (EPHA2) (ABIN7533760)
抗原
See all EPH Receptor A2 (EPHA2) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Active Recombinant Human EphA2/ECK Protein
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序列
- DPNQAVLKFT TEIHPSCVTR QKVIGAGEFG EVYKGMLKTS SGKKEVPVAI KTLKAGYTEK QRVDFLGEAG IMGQFSHHNI IRLEGVISKY KPMMIITEYM ENGALDKFLR EKDGEFSVLQ LVGMLRGIAA GMKYLANMNY VHRDLAARNI LVNSNLVCKV SDFGLSRVLE DDPEATYTTS GGKIPIRWTA PEAISYRKFT SASDVWSFGI VMWEVMTYGE RPYWELSNHE VMKAINDGFR LPTPMDCPSA IYQLMMQCWQ QERARRPKFA DIVSILDKLI RAPDSLKTLA DFDPRVSIRL PSTSGSEGVP FRTVSEWLES IKMQQYTEHF MAAGYTAIEK VVQMTNDDIK RIGVRLPGHQ KRIAYSLLGL KDQVNTVGIP I
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特异性
- Asp596-Ile976
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过滤
- 0.22 μm filtered
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内毒素水平
- < 1.0 EU/μg of the protein by LAL method.
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human EphA2 at 1 μg/mL (100 μL/well) can bind Human EFNA1 with a linear range of 4.883 ng/mL-9.206 μg/mL.
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EPH Receptor A2 (EPHA2) (AA 24-537) protein (His tag)
EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 26-538) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (His-Avi Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (Fc Tag)EPHA2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
EPH Receptor A2 (EPHA2) (AA 24-534) protein (His tag)EPHA2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
EPH Receptor A2 (EPHA2) (AA 1-976) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 204-326) protein (GST tag)EPHA2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor A2 (EPHA2) (AA 26-535) protein (His tag)EPHA2 宿主: 小鼠 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
EPH Receptor A2 (EPHA2) (AA 585-976) (Active) protein (GST tag,His tag)EPHA2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
EPH Receptor A2 (EPHA2) (Active) protein (His tag)EPHA2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
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储存条件
- -20 °C,-80 °C
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储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- EPH Receptor A2 (EPHA2)
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别名
- EphA2/ECK
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背景
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Description: Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family.The receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.
Name: ARCC2,CTPA,CTPP1,CTRCT6,ECK,EPHA2
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基因ID
- 1969
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UniProt
- P29317
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途径
- RTK signaling
抗原
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