GSTP1 Protein (AA 2-210) (His tag)
Quick Overview for GSTP1 Protein (AA 2-210) (His tag) (ABIN7505497)
抗原
See all GSTP1 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 2-210
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标记
- This GSTP1 protein is labelled with His tag.
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序列
- Pro 2-Gln 210
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产品特性
- A DNA sequence encoding the rat GSTp1 protein (P04906) (Pro 2-Gln 210) was expressed with N-His tag.
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Glutathione S-Transferase pi 1 (GSTP1) (AA 1-210) protein (GST tag)
GSTP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))
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别名
- GSTp1
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背景
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Abbreviation: GSTp1
Target Synonym: Glutathione S-transferase P,Gstp1,GSTP1_RAT
Background: Glutathione S-Transferases (GSTs) are members of the phase II detoxification enzyme family that conjugate glutathione to various electrophilic compounds, including metabolites generated by oxidative processes in the body, environmental toxins or carcinogens, and anti-cancer drugs. GSTP1 is a cytosolic protein that belongs to pi class of the GST superfamily. It is crystallized as a homodimer, but also exists in solution as an equilibrium mixture of monomer and dimer, depending on the protein concentration. Four genetic variants of GSTP1 with different enzymatic activities have been identified, which indicates the particular allelic form expressed in tissues could contribute to variation in catalytic efficiency and biological functions. Genetic polymorphisms and expression patterns of GSTP1 have been associated with a variety of effects on human cancer, anti-cancer drug resistance, and asthma. In addition to its role as a drug-metabolizing enzyme, GSTP1 has ligand binding properties and regulates kinase signaling pathways through protein-protein interactions.
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分子量
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Calculated MW: 22.88 kDa
Observed MW: 31 kDa
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UniProt
- P04906
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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