Merlin Protein (AA 1-595) (His tag)
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- 抗原 See all Merlin (NF2) 蛋白
- Merlin (NF2) (Neurofibromin 2 (NF2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-595
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Merlin protein is labelled with His tag.
- 应用范围
- Immunogen (Imm)
- 序列
- Met1-Leu595
- 产品特性
- A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product NF2 蛋白
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Neurofibromin 2 (NF2) (AA 1-595) protein (His tag)
custom-made NF2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Neurofibromin 2 (NF2) (AA 1-596) protein (His tag)custom-made NF2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Neurofibromin 2 (NF2) (AA 1-82) protein (GST tag)NF2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neurofibromin 2 (NF2) proteinNF2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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used as Immunogen for (ABIN6999888, ABIN7234196, ABIN7234197 and ABIN7234198)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
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Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Merlin (NF2) (Neurofibromin 2 (NF2))
- 别名
- Merlin (NF2 产品)
- 背景
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Abbreviation: Merlin,NF2
Target Synonym: CAN,BANF,Bilateral acoustic neuroma,MERL_HUMAN,Merlin,Moesin ezrin radixin like protein,Moesin ezrin radizin like,Moesin-ezrin-radixin-like,Neurofibromatosis 2,Neurofibromatosis type 2,Neurofibromatosis2,NF 2,SCH,Schwannomerlin
Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
- 分子量
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Calculated MW: 69.7 kDa
Observed MW: 68-71 kDa
- UniProt
- P35240-1
- 途径
- Cell-Cell Junction Organization
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