IL-3 Protein (His tag)
Quick Overview for IL-3 Protein (His tag) (ABIN7447933)
抗原
See all IL-3 蛋白蛋白类型
宿主
资源
纯度
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标记
- This IL-3 protein is labelled with His tag.
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原理
- Cynomolgus IL-3 Protein, His Tag
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序列
- Ala 20 -Gln 143
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产品特性
- Cynomolgus IL-3, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 20 -Gln 143 (Accession # G7P877-1).
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内毒素水平
- 1.0 EU per μg
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说明
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This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 18-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- -20°C
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- IL-3 (Interleukin 3 (IL-3))
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别名
- IL-3
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背景
- Synonyms:IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3,Description:Interleukin 3 is also known as IL-3, is a protein that in humans is encoded by the IL3 gene. Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. The IL-3 receptor is a heterodimer of the IL-3 specific α-chain and the common β-chain, βc, which is also used by GM-CSF and IL-5. [3] Binding of IL-3 can also involve substitution of the βc by a βIL-3-chain that appears to be specific for IL-3 . Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats, and the PI3K/Akt pathway. IL-3 may play an important role in the development of airway inflammation associated with asthma. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.
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分子量
- 15.9 kDa
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途径
- JAK/STAT Signaling, Regulation of Carbohydrate Metabolic Process, Autophagy
抗原
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