CD80 Protein (CD80) (Biotin,Fc-Avi Tag)
Quick Overview for CD80 Protein (CD80) (Biotin,Fc-Avi Tag) (ABIN7316777)
抗原
See all CD80 蛋白蛋白类型
宿主
资源
纯度
质量等级
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标记
- This CD80 protein is labelled with Biotin,Fc-Avi Tag.
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原理
- Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified)
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序列
- Val 35 - Asn 242
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产品特性
- Biotinylated Human B7-1 / CD80,Fc,Avitag is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).
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内毒素水平
- 1.0 EU per μg
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CD80 (CD80) (AA 35-242) protein (His-Avi Tag)
CD80 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD80 (CD80) (AA 35-242) protein (His-Avi Tag,Biotin)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD80 (CD80) (AA 35-242) protein (mFc-His Tag)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD80 (CD80) (AA 35-242) protein (His tag)HPLC verified CD80 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
CD80 (CD80) (AA 137-230) protein (His-DYKDDDDK-Strep II Tag)CD80 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD80 (CD80) (AA 35-242) protein (His-DYKDDDDK-Strep II Tag)CD80 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD80 (CD80) (AA 38-245) (Active) protein (Fc Tag)CD80 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD80 (CD80) (AA 35-242) (Active) protein (Fc Tag,AVI tag,Biotin)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
CD80 (CD80) protein (His tag)CD80 宿主: 兔 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
CD80 (CD80) protein (Fc Tag)CD80 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
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说明
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This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 52.0 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl, pH 7.5
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储存条件
- -20 °C
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储存方法
- -20°C
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- CD80
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别名
- B7-1
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背景
- Synonyms:CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7,Description:B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
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分子量
- 52.0 kDa
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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