CD80 Protein (CD80) (AA 38-245) (Fc Tag)
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Quick Overview for CD80 Protein (CD80) (AA 38-245) (Fc Tag) (ABIN2870713)
抗原
See all CD80 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 38-245
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标记
- This CD80 protein is labelled with Fc Tag.
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序列
- AA 38-245
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产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.3 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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CD80 (CD80) (AA 35-242) (Active) protein (His-Avi Tag)
CD80 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD80 (CD80) (AA 35-242) (Active) protein (Biotin,His-Avi Tag)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD80 (CD80) (AA 35-242) protein (His tag,mFc Tag)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
CD80 (CD80) (AA 35-242) protein (His tag)HPLC verified CD80 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
CD80 (CD80) (AA 137-230) protein (His-DYKDDDDK-Strep II Tag)CD80 宿主: 人 宿主: HEK-293T Cells Recombinant WB, ELISA, SDS, PI
CD80 (CD80) (AA 35-242) protein (His-DYKDDDDK-Strep II Tag)CD80 宿主: 人 宿主: HEK-293T Cells Recombinant WB, ELISA, SDS, PI
CD80 (CD80) (AA 35-242) (Active) protein (Fc Tag,AVI tag,Biotin)CD80 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
CD80 (CD80) protein (His tag)CD80 宿主: 兔 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
CD80 (CD80) protein (Fc Tag)CD80 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
CD80 (CD80) protein (His tag)CD80 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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- CD80
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别名
- B7-1
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背景
- B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
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分子量
- 50.3 kDa
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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