LRP5 Protein (AA 644-1263) (Fc Tag)
Quick Overview for LRP5 Protein (AA 644-1263) (Fc Tag) (ABIN7275208)
抗原
See all LRP5 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 644-1263
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标记
- This LRP5 protein is labelled with Fc Tag.
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原理
- Human LRP-5 Protein
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序列
- Glu644-Gln1263
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产品特性
- Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu644-Gln1263.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human DKK1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LPR-5, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA. See testing image for detail.
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Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (AA 644-1263) (Active) protein (Fc Tag)
LRP5 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (AA 644-1263) protein (mFc Tag)LRP5 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (AA 41-130) protein (GST tag)LRP5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as 0.22μm filtered solution in PBS, 100 mM L-arginine ( pH 7.4).
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储存条件
- -80 °C
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储存方法
- Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
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别名
- LRP-5
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背景
- A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.
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分子量
- 96.51 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.
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UniProt
- O75197-1
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途径
- WNT signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
抗原
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