DDR1 Protein (AA 21-417) (His tag)
Quick Overview for DDR1 Protein (AA 21-417) (His tag) (ABIN7274460)
抗原
See all DDR1 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 21-417
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标记
- This DDR1 protein is labelled with His tag.
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原理
- Human DDR1 Protein
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序列
- Asp21-Ala417
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产品特性
- Recombinant Human DDR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp21-Ala417.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human DDR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-DDR1 Antibody, hFc Tag with the EC50 of 12.8ng/ml determined by ELISA. The affinity constant of 0.806 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 22-415) protein (His tag)
DDR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 21-416) protein (His tag)DDR1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 278-377) protein (GST tag)DDR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 22-876) protein (GST tag)DDR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (Active) protein (GST tag,His tag)DDR1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (Active) protein (GST tag,His tag)DDR1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 89 % as determined by reducing SDS-PAGE. Active
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) protein (Fc Tag)DDR1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) protein (His tag)DDR1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) protein (Fc Tag)DDR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 21-417) protein (hIgG-His-tag)DDR1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
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别名
- DDR1
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背景
- Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways, however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.
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分子量
- 45.1 kDa. Due to glycosylation, the protein migrates to 63-67 kDa based on Tris-Bis PAGE result.
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UniProt
- Q08345-1
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途径
- RTK signaling, Smooth Muscle Cell Migration
抗原
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