SHP1 Protein (AA 207-597) (His-GST)
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Quick Overview for SHP1 Protein (AA 207-597) (His-GST) (ABIN7320120)
抗原
See all SHP1 (PTPN6) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 207-597
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标记
- This SHP1 protein is labelled with His-GST.
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原理
- Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)
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序列
- Ala207-Lys597
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产品特性
- A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006. The specific activity is > 4 μmoles/min/μg.
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Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-597) protein (GST tag)
PTPN6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, PAA, AP, AA
Protein-tyrosine Phosphatase 1C (PTPN6) (AA 5-163) protein (His-IF2DI Tag)PTPN6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Protein-tyrosine Phosphatase 1C (PTPN6) (AA 243-541) (Active) proteinPTPN6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, EAA Active
Protein-tyrosine Phosphatase 1C (PTPN6) (Active) proteinPTPN6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % pure SDS Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.0, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
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别名
- PTPN6/SH-PTP1
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背景
- 70Z-SHP,Hcph,PTPTY-42,Ptp1C,SH-PTP1,SHP-1,hcp,me,PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
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分子量
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Calculated MW: 72.7 kDa
Observed MW: 63 kDa
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UniProt
- P29351
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
抗原
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