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Quick Overview for NOTCH2 Protein (His tag) (ABIN7319906)
抗原
See all NOTCH2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This NOTCH2 protein is labelled with His tag.
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原理
- Recombinant Human Notch2 (C-6His)
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序列
- Leu26-Gln530
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产品特性
- Recombinant Human Neurogenic Locus Notch Homolog Protein 2 is produced by our Mammalian expression system and the target gene encoding Leu26-Gln530 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Notch 2 (NOTCH2) (AA 26-530) protein (His-Avi Tag,Biotin)
NOTCH2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Notch 2 (NOTCH2) (AA 26-530) (Active) protein (Fc Tag)NOTCH2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Notch 2 (NOTCH2) (AA 27-136) protein (GST tag)NOTCH2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- NOTCH2 (Notch 2 (NOTCH2))
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别名
- Notch2
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背景
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Background: Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Human Notch-2 ECD (aa 26-530) shows 93 % , 93 %, 96 % and 96 % aa identity with the corresponding regions of mouse, rat, canine, and bovine Notch-2, respectively. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.
Synonym: AGS2, hN2, Notch homolog 2, Notch2, Notch-2, HJCYS
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分子量
- 54.9 kDa
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UniProt
- Q04721
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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