电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

NOTCH2 Protein (His tag)

This Recombinant NOTCH2 protein is expressed in 人细胞.
产品编号 ABIN7319906
发货至: 中国

Quick Overview for NOTCH2 Protein (His tag) (ABIN7319906)

抗原

See all NOTCH2 蛋白
NOTCH2 (Notch 2 (NOTCH2))

蛋白类型

Recombinant

宿主

  • 7
  • 2

资源

  • 3
  • 2
  • 2
  • 1
  • 1
人细胞

纯度

>95 % as determined by reducing SDS-PAGE.
  • 标记

    This NOTCH2 protein is labelled with His tag.

    原理

    Recombinant Human Notch2 (C-6His)

    序列

    Leu26-Gln530

    产品特性

    Recombinant Human Neurogenic Locus Notch Homolog Protein 2 is produced by our Mammalian expression system and the target gene encoding Leu26-Gln530 is expressed with a 6His tag at the C-terminus.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.
  • 想要此Protein的其他选项吗?

    !
    探索我们的预定义定制蛋白和定制蛋白服务!

    您的项目需要进一步定制吗?联系我们,了解我们的定制蛋白解决方案

  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    NOTCH2 (Notch 2 (NOTCH2))

    别名

    Notch2

    背景

    Background: Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Human Notch-2 ECD (aa 26-530) shows 93 % , 93 %, 96 % and 96 % aa identity with the corresponding regions of mouse, rat, canine, and bovine Notch-2, respectively. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.

    Synonym: AGS2, hN2, Notch homolog 2, Notch2, Notch-2, HJCYS

    分子量

    54.9 kDa

    UniProt

    Q04721

    途径

    Notch Signaling, Stem Cell Maintenance
You are here:
Chat with us!