NGFB Protein (AA 122-239)
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Quick Overview for NGFB Protein (AA 122-239) (ABIN7319222)
抗原
See all NGFB 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 122-239
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原理
- Recombinant Human β-NGF/NGFB Protein (aa 122-239, Human Cells)
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序列
- Ser122-Arg239
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产品特性
- Recombinant Human beta-Nerve Growth Factor is produced by our Mammalian expression system and the target gene encoding Ser122-Arg239 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.04-0.4 ng/ml.
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Nerve Growth Factor beta (NGFB) protein
NGFB 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE. AM, ADA, IA, ScA
Nerve Growth Factor beta (NGFB) (AA 130-239) (Active) proteinNGFB 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE. CC Active
Nerve Growth Factor beta (NGFB) proteinNGFB 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Nerve Growth Factor beta (NGFB) proteinNGFB 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Nerve Growth Factor beta (NGFB) proteinNGFB 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- NGFB (Nerve Growth Factor beta (NGFB))
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别名
- beta-NGF/NGFB
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背景
- Beta-NGF,Beta-Nerve Growth Factor,NGF,NGFB,Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90 % sequence similarity with mouse protein and shows cross-species reactivity.
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分子量
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Calculated MW: 13.3 kDa
Observed MW: 14 kDa
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基因ID
- 4803
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UniProt
- P01138
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途径
- NF-kappaB Signaling, RTK signaling, Regulation of Cell Size
抗原
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