IL-8 Protein (AA 23-99)
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北京 101111
Quick Overview for IL-8 Protein (AA 23-99) (ABIN7317013)
抗原
See all IL-8 (IL8) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 23-99
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原理
- Recombinant Human IL-8/CXCL8 Protein (aa 23-99)
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序列
- Ala 23-Ser 99
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产品特性
- The 77 amino acid endothelial-cell derived form (Ala 23-Ser 99) of the mature human IL8 (NP_000575.1) was expressed and purified.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Interleukin 8 (IL8) (AA 28-99) (Active) protein (His tag,AVI tag,Biotin)
IL8 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 8 (IL8) (AA 28-99) (Active) proteinIL8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant CMA Active
Interleukin 8 (IL8) (AA 1-99) protein (GST tag)IL8 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 8 (IL8) (AA 28-99) protein (His tag)IL8 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. IA, ScA, ADA, AM
Interleukin 8 (IL8) (AA 26-167) protein (His-IF2DI Tag)IL8 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 8 (IL8) (AA 28-99) (Active) protein (His tag)IL8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
Interleukin 8 (IL8) (AA 28-99) protein (Fc Tag)IL8 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Interleukin 8 (IL8) (AA 23-101), (full length) protein (His tag)IL8 宿主: 犬 宿主: 酵母菌 Recombinant > 90 % ELISA
Interleukin 8 (IL8) (AA 28-99) (Active) protein (Fc Tag)IL8 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IL-8 (IL8) (Interleukin 8 (IL8))
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别名
- IL-8/CXCL8
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背景
- CXCL,Interleukin,C-X-C motif chemokine,Chemokine (C-X-C motif) ligand,IL8/CXCL,GCP,NAP,CXCL8,GCP-1,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1,NAP1,3-10C,AMCF-I,IL8/CXCL8,K60,Interleukin-8,IL-8,Emoctakin,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Granulocyte chemotactic protein 1 (GCP-1),Monocyte-derived neutrophil chemotactic factor (MDNCF),(Ala-IL-8)77,(Ser-IL-8)72,9E3,Beta thromboglobulin like protein,CEF-4,chemokine,CXC motif,GCP/IL-8 protein I,GCP/IL-8 protein II,GCP/IL-8 protein III,GCP/IL-8 protein IV,GCP/IL-8 protein V,GCP/IL-8 protein VI,Granulocyte chemotactic protein 1,IL-8(1-77),IL-8(9-77),IL8/NAP1 form I,IL8/NAP1 form II,IL8/NAP1 form III,IL8/NAP1 form IV,IL8/NAP1 form V,IL8/NAP1 form VI,Inteleukin 8,ligand 8,Lymphocyte-derived neutrophil-activating factor,MDNCF-b,MDNCF-c,Monocyte-derived neutrophil chemotactic factor,Monocyte-derived neutrophil-activating peptide,Neutrophil activating peptide 1,Neutrophil activating protein 1,Neutrophil-activating factor,Neutrophil-activating protein 1,Protein 3 10C,Protein 3-10C,SCYB8,Small inducible cytokine subfamily B member 8,T cell chemotactic factor,T-cell chemotactic factor,TSG1,Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental chang. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer.
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分子量
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Calculated MW: 8.0 kDa
Observed MW: 12 kDa
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基因ID
- 3576
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NCBI登录号
- NP_000575
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UniProt
- P10145
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途径
- TLR signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagy
抗原
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