IDO1 蛋白
-
- 抗原 See all IDO1 蛋白
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human IDO1/IDO Protein (Active)
- 序列
- Ala2-Gly403
- 产品特性
- A DNA sequence encoding the human IDO1 (NP_002155.1) (Ala2-Gly403) was expressed and purified with one additional amino acids (Gly) at the N-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine.The specific activity is > 500 pmoles/min/μg.
- Top Product
- Discover our top product IDO1 蛋白
-
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (His tag)
IDO1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (GST tag)IDO1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Indoleamine 2,3-Dioxygenase 1 (IDO1) protein (His tag)IDO1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 304-403) protein (GST tag)IDO1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (Strep Tag)Crystallography grade IDO1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-407) protein (Strep Tag)Crystallography grade IDO1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (Active) protein (Myc-DYKDDDDK Tag)IDO1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM NaAC, 100 mM Nacl, 20 % glycerol, pH 5.5.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- 别名
- IDO1/IDO (IDO1 产品)
- 别名
- INDO Protein, ido Protein, indo Protein, IDO Protein, cd107b Protein, IDO1 Protein, IDO-1 Protein, Ido Protein, Indo Protein, indoleamine 2,3-dioxygenase 1 Protein, indoleamine 2,3-dioxygenase 1 L homeolog Protein, indoleamine 2,3-dioxygenase 1-like Protein, IDO1 Protein, ido1.L Protein, ido1 Protein, Ido1 Protein, LOC100050681 Protein
- 背景
-
Background: Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesCo-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Indole 2;3-dioxygenase; Indoleamine 2;3-dioxygenase 1; IDO-1; IDO1; IDO; INDO
- 分子量
- 45.2 kDa
- NCBI登录号
- NP_002155
- 途径
- Activated T Cell Proliferation
-
