Granulin Protein (GRN) (His tag)
Quick Overview for Granulin Protein (GRN) (His tag) (ABIN7320292)
抗原
See all Granulin (GRN) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Granulin protein is labelled with His tag.
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原理
- Recombinant Mouse Granulin/GRN/Progranulin Protein (His Tag)
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序列
- Met 1-Leu 589
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产品特性
- A DNA sequence encoding the mouse GRN (NP_032201.2) (Met 1-Leu 589) was fused with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 1-593) protein (GST tag)GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) (AA 364-430) protein (His tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Granulin (GRN)
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别名
- Granulin/GRN/Progranulin
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物质类
- Viral Protein
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背景
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Background: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.
Synonym: epithelin,Pgrn
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分子量
- 63 kDa
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NCBI登录号
- NP_032201
抗原
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