Quick Overview for FLT4 Protein (His tag) (ABIN7195831)
抗原
See all FLT4 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This FLT4 protein is labelled with His tag.
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原理
- Recombinant Mouse VEGFR3/FLT4 Protein (His Tag)(Active)
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序列
- Met 1-Glu 775
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产品特性
- A DNA sequence encoding the mouse FLT4 (P35917-1) extracellular domain (Met 1-Glu 775) was expressed, with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse VEGFR3-His at 10 μg/mL (100 μl/well) can bind mouse Fc-VEGFD, The EC50 of mouse Fc-VEGFD is 44 ng/mL.
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Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-776) protein (Fc Tag)
FLT4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-776) protein (His-Avi Tag)FLT4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-776) protein (His-Avi Tag,Biotin)FLT4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-776) (Active) protein (Fc Tag)FLT4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Fms-Related Tyrosine Kinase 4 (FLT4) (Active) protein (Fc Tag)FLT4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-770) (Active) protein (Fc Tag)FLT4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-776) (Active) protein (His tag,AVI tag,Biotin)FLT4 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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别名
- VEGFR3/FLT4
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背景
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Background: Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: AI323512;Chy;Flt-4;VEGFR-3;VEGFR3
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分子量
- 86.4 kDa
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
抗原
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