ESAM 蛋白
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北京 101111
Quick Overview for ESAM 蛋白 (ABIN7317973)
抗原
See all ESAM 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human ESAM Protein
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序列
- Met 1-Ala 248
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产品特性
- The mature form of human ESAM (NP_620411.2) extracellular domain (Met 1-Ala 248) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Endothelial Cell Adhesion Molecule (ESAM) protein (His tag)
ESAM 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) protein (GST tag)ESAM 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
Endothelial Cell Adhesion Molecule (ESAM) protein (Fc Tag)ESAM 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- ESAM (Endothelial Cell Adhesion Molecule (ESAM))
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别名
- ESAM
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背景
- W117m,Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.
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分子量
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Calculated MW: 24.5 kDa
Observed MW: 40-45 kDa
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基因ID
- 90952
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NCBI登录号
- NP_620411
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UniProt
- Q96AP7
抗原
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