Cathepsin B Protein (CTSB) (His tag)
Quick Overview for Cathepsin B Protein (CTSB) (His tag) (ABIN7318252)
抗原
See all Cathepsin B (CTSB) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Cathepsin B protein is labelled with His tag.
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原理
- Recombinant Human Cathepsin B/CTSB Protein (His Tag)
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序列
- Arg18-Ile339
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产品特性
- Recombinant Human Cathepsin B is produced by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Cathepsin B (CTSB)
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别名
- Cathepsin B/CTSB
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背景
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Background: Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes
Synonym: Cathepsin B, APP Secretase, APPS, Cathepsin B1, CTSB, CPSB
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分子量
- 36.9 kDa
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UniProt
- P07858
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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