MERTK 蛋白
Quick Overview for MERTK 蛋白 (ABIN7194461)
抗原
See all MERTK 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human MERTK/Mer Protein
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序列
- Met 1-Ala 499
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产品特性
- The mature form of human Mer (NP_006334.2) extracellular domain (Met 1-Ala 499) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (mFc Tag)
MERTK 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 19-497) protein (His tag)MERTK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (His tag)MERTK 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (Fc Tag)MERTK 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (Fc Tag)MERTK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) protein (GST tag)MERTK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (GST tag,His tag)MERTK 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Active) protein (GST tag,His tag)MERTK 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 96 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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别名
- MERTK/Mer
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背景
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Background: Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.
Synonym: Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK, MER, Mer
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分子量
- 54 kDa
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NCBI登录号
- NP_006334
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途径
- RTK signaling
抗原
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