LRRC15 Protein (AA 22-538) (His tag)
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- 抗原 See all LRRC15 products
- LRRC15 (Leucine Rich Repeat Containing 15 (LRRC15))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-538
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This LRRC15 protein is labelled with His tag.
- 产品特性
- Human LRRC15 / LIB Protein, His Tag (MALS verified)
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Leucine Rich Repeat Containing 15 (LRRC15) (AA 22-538) protein (His-Avi Tag)
LRRC15 宿主: 人 宿主: CHO Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leucine Rich Repeat Containing 15 (LRRC15) (AA 22-538) protein (His-Avi Tag,Biotin)LRRC15 宿主: 人 宿主: CHO Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leucine Rich Repeat Containing 15 (LRRC15) (AA 22-538) protein (His tag)LRRC15 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leucine Rich Repeat Containing 15 (LRRC15) (AA 22-536) protein (His tag)LRRC15 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
Leucine Rich Repeat Containing 15 (LRRC15) (AA 47-565) protein (His tag)LRRC15 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leucine Rich Repeat Containing 15 (LRRC15) (AA 22-538) protein (His tag,AVI tag,Biotin)LRRC15 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- 应用备注
- MALS verified
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
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- 抗原
- LRRC15 (Leucine Rich Repeat Containing 15 (LRRC15))
- 别名
- LRRC15 (LRRC15 产品)
- 背景
- LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody-drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
- 分子量
- 59.8 kDa
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