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CCL2 Protein (AA 24-99) (Fc Tag)

This Recombinant CCL2 protein is expressed in HEK-293 Cells.
产品编号 ABIN6964235
发货至: 中国

Quick Overview for CCL2 Protein (AA 24-99) (Fc Tag) (ABIN6964235)

抗原

See all CCL2 蛋白
CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

蛋白类型

Recombinant

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HEK-293 Cells

纯度

The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
  • 产品特性

    AA 24-99

    标记

    This CCL2 protein is labelled with Fc Tag.

    原理

    Recombinant human CCL2 protein with C-terminal human Fc tag

    特异性

    CCL2 (Gln24-Thr99) hFc (Glu99-Ala330)

    产品特性

    Extracellular Domain Protein

    纯化方法

    Purified from cell culture supernatant by affinity chromatography
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    有效期

    12 months
  • 抗原

    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

    别名

    CCL2

    背景

    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. [provided by RefSeq, Aug 2020]

    分子量

    predicted molecular mass of 34.8 kDa after removal of the signal peptide. The apparent molecular mass of CCL2-hFc is 35-55 kDa due to glycosylation.

    UniProt

    P13500

    途径

    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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