GRN
宿主: 人
宿主: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
WB, SDS, Imm, ELISA, AcA
Active
限制
仅限研究用
状态
Liquid
缓冲液
The protein solution contains 1x PBS.
储存条件
-20 °C
抗原
Granulin (GRN)
别名
Progranulin
物质类
Viral Protein
背景
Progranulin Human Recombinant fused to DYKDDDDK at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 AA and having a molecular mass of 88 kDa. The Progranulin is purified by standard chromatographic techniques. Introduction: A 88 kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Synonyms: GRN, PGRN, granulin, Acrogranin, propithelin, PC cell derived growth Factor, GEP, GP88, PEPI, PCDGF.