CD19 蛋白
Quick Overview for CD19 蛋白 (ABIN2746374)
抗原
See all CD19 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Purified Protein in ready-to-use SDS sample buffer.
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特异性
- The antibody labels a strong band of CD19 at 67 kDa in ABIN1741617 samples and in other cancer cell lines.
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纯化方法
- Purified Protein
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CD19 Molecule (CD19) (AA 20-291) protein (His tag,FITC)
CD19 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD19 Molecule (CD19) (AA 20-291) (Active) protein (His tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
CD19 Molecule (CD19) (AA 20-291) (Active) protein (Fc Tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD19 Molecule (CD19) (AA 20-291) (Active) protein (Fc Tag,Biotin)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
CD19 Molecule (CD19) (AA 21-291) protein (His tag)CD19 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD19 Molecule (CD19) (AA 20-291) protein (His tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD19 Molecule (CD19) (AA 20-291) protein (Fc-His Tag)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD19 Molecule (CD19) (AA 20-291) (Active) protein (His tag,AVI tag,Biotin)CD19 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
CD19 Molecule (CD19) (AA 19-287) protein (His tag)CD19 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
CD19 Molecule (CD19) (AA 1-556) protein (GST tag)CD19 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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应用备注
- The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
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说明
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Synonyms: B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD_antigen=CD19, B lymphocyte antigen CD19, B lymphocyte surface antigen B4 antibody, Leu12 antibody, Lymphocyte Surface Antigen antibody, MGC109570 antibody, MGC12802 antibody, T-cell surface antigen Leu-12 antibody.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
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储存条件
- -20 °C
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储存方法
- -20 °C for long term storage
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- CD19 (CD19 Molecule (CD19))
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别名
- CD19
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背景
- CD19 (Cluster of Differentiation 19) also known as B4, is a 95 kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. It contains two extracellular immunoglobulin-like domains and is selectively expressed on the cell surface of B-lymphocytes, where it activates intracellular signaling cascades. CD19 antigen is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets. In normal peripheral blood, 8-20 % of lymphocytes express CD19 antigen, but plasma cells do not express this antigen. CD19 antigen plays a role in regulating B cell proliferation.The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecules to the receptor. After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. The phosphorylation at these sites mediates elevated intracellular calcium response, as well as the JNK pathway. Defects in CD19 causes common variable immunodeficiency type 3 (CVID3) also called antibody deficiency due to CD19 defect. CVID3 is characterized by hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins. Adoptive T-cell therapy with CD19-specific chimeric antigen receptors (CARs) is promising for treatment of advanced B-cell malignancies. CD19-CAR T-cells enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma. The human CD19 gene maps to chromosome 16p11.2 and encodes a 557 amino acid protein.
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分子量
- 76 kDa
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UniProt
- P15391
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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