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CCL3 Protein (AA 24-92)

This Recombinant CCL3 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN2666877
发货至: 中国

Quick Overview for CCL3 Protein (AA 24-92) (ABIN2666877)

抗原

See all CCL3 蛋白
CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

蛋白类型

Recombinant

生物活性

Active

宿主

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小鼠

资源

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大肠杆菌(E. Coli)

应用范围

ELISA, Flow Cytometry (FACS)

纯度

> 97 % , as determined by Coomassie stained SDS-PAGE.
  • 产品特性

    AA 24-92

    过滤

    0.22 μm filtered

    内毒素水平

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Biological activity: Bioactivity was measured by its ability to chemoattract Baf3-hCCR5 cells in a dose dependent manner.

    限制

    仅限研究用
  • 状态

    Liquid

    溶解方式

    For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.

    缓冲液

    0.22 μm filtered protein solution is in 20 mM Glycine, 150 mM NaCl, pH 3.0.

    注意事项

    Avoid repeated freeze/thaw cycles.

    储存条件

    -20 °C

    储存方法

    Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
  • 抗原

    CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

    别名

    CCL3

    背景

    CCL3 is a chemokine belonging to the CC chemokine family. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation. In addition to regulating leukocyte migration, CCL3 enhances IFN-γ secretion from activated T cells and thus induces Th1 response. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. Also, CCL3 expression is increased during atherosclerotic lesion formation in mice, and CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation. Previous data has shown that CCL3 uses CCR1 to promote neutrophil recruitment in OVA-challenged, immunized mice.

    分子量

    The 69 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kDa. The DTT-reduced protein migrates at approximately 12 kDa and non-reduced protein migrates at approximately 14 kDa by SDS-PAGE. The predicted N-terminal amino ac

    途径

    Cellular Response to Molecule of Bacterial Origin, Autophagy
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