VEGF121 Protein (AA 27-147)
(1 reference)Quick Overview for VEGF121 Protein (AA 27-147) (ABIN2181899)
抗原
See all VEGF121 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 27-147
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品牌
- ActiveMax®
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序列
- AA 27-147
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产品特性
- This protein carries no "tag". The protein has a calculated MW of 14 kDa (monomer). As a result of glycosylation, the protein migrates as 19 kDa and 20 kDa under reducing (R) condition, and 40-45 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE).
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Vascular Endothelial Cell Growth Factor 121 (VEGF121) (AA 27-147) protein (His-Avi Tag,Biotin)
VEGF121 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Vascular Endothelial Cell Growth Factor 121 (VEGF121) (AA 27-147) protein (His-Avi Tag)VEGF121 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Vascular Endothelial Cell Growth Factor 121 (VEGF121) (AA 28-147) (Active) protein (His tag)VEGF121 宿主: 人 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
Vascular Endothelial Cell Growth Factor 121 (VEGF121) (Isoform 121) proteinVEGF121 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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: "In vitro Fab display: a cell-free system for IgG discovery." in: Protein engineering, design & selection : PEDS, Vol. 27, Issue 4, pp. 97-109, (2014) (PubMed).
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: "In vitro Fab display: a cell-free system for IgG discovery." in: Protein engineering, design & selection : PEDS, Vol. 27, Issue 4, pp. 97-109, (2014) (PubMed).
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- VEGF121 (Vascular Endothelial Cell Growth Factor 121 (VEGF121))
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别名
- VEGF-121
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背景
- Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term, and show defects in skeletogenesis. Human VEGF121 shares 87 % aa sequence identity with corresponding regions of mouse and rat, 93 % with feline, equine and bovine, and 91 %, 95 % and 96 % with ovine, canine and porcine VEGF, respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C.
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分子量
- 14.1 kDa
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NCBI登录号
- NP_001165099
抗原
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