MME Protein (AA 52-750)
(1 reference)Quick Overview for MME Protein (AA 52-750) (ABIN2181505)
抗原
See all MME 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 52-750
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序列
- AA 52-750
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产品特性
- rhCD10, with Gly-Pro at the N- terminus, has a calculated MW of 80 kDa. The predicted N-terminus is Tyr 52. The reducing (R) protein migrates as 90-100 kDa due to glycosylation.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Membrane Metallo-Endopeptidase (MME) (AA 52-750) protein (His tag)
MME 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Membrane Metallo-Endopeptidase (MME) (AA 52-750) protein (His tag)MME 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Membrane Metallo-Endopeptidase (MME) (AA 53-750) protein (His tag)MME 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Membrane Metallo-Endopeptidase (MME) (AA 1-750) protein (GST tag)MME 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Membrane Metallo-Endopeptidase (MME) protein (Fc Tag)MME 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Membrane Metallo-Endopeptidase (MME) protein (His tag)MME 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Membrane Metallo-Endopeptidase (MME) (AA 52-750) protein (His tag)MME 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 20 mM Tris, 100 mM NaCl, pH 8.0
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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: "Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels." in: Diabetologia, Vol. 60, Issue 4, pp. 701-708, (2017) (PubMed).
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: "Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels." in: Diabetologia, Vol. 60, Issue 4, pp. 701-708, (2017) (PubMed).
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- MME (Membrane Metallo-Endopeptidase (MME))
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别名
- Neprilysin
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物质类
- Chemical
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背景
- Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110- kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).
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分子量
- 80.0 kDa
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NCBI登录号
- NP_000893
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途径
- RTK signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
抗原
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