FZD2 Protein (AA 24-156) (Fc Tag)
FZD2
宿主: 人
宿主: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
1 image
(2 references)-
- 抗原 See all FZD2 蛋白
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 24-156
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This FZD2 protein is labelled with Fc Tag.
- 序列
- AA 24-156
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.7 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
-
Frizzled Family Receptor 2 (FZD2) (AA 24-190) protein (Fc Tag)
FZD2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
-
-
: "Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive." in: Toxins, Vol. 12, Issue 12, (2020) (PubMed).
: "Frizzled proteins are colonic epithelial receptors for C. difficile toxin B." in: Nature, Vol. 538, Issue 7625, pp. 350-355, (2017) (PubMed).
-
: "Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive." in: Toxins, Vol. 12, Issue 12, (2020) (PubMed).
-
- 抗原
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- 别名
- Frizzled-2 (FZD2 产品)
- 背景
- Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
- 分子量
- 41.7 kDa
- 途径
- WNT signaling
-
You are here:
