FcRn Protein (AA 24-297) (His tag,Strep Tag)
(3 references)-
- 抗原 See all FcRn 蛋白
- FcRn (neonatal Fc Receptor (FcRn))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 24-297
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宿主
- Cynomolgus, 猕猴
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资源
- HEK-293 Cells
- 标记
- This FcRn protein is labelled with His tag,Strep Tag.
- 品牌
- MABSol®
- 序列
- AA 24-297
- 产品特性
- Cynomolgus / Rhesus macaque FcRn / FCGRT & B2M Heterodimer Protein, produced by co-expression of FCGRT and B2M, has a calculated MW of 31.3 kDa (FCGRT) and 13.1 kDa (B2M). Subunit FCGRT is fused with his-tag at the C-terminus and subunit Beta-2 microglobulin (B2M) is fused with Strep II-tag at the C-terminus. The predicted N-terminus is Ala 24 (FCGRT) & Ile 21(B2M). The reducing (R) protein migrates as 33 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation. Cynomolgus and Rhesus macaque FcRn / FCGRT & B2M sequences are identical.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FcRn 蛋白
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neonatal Fc Receptor (FcRn) (AA 24-297) protein (His tag)
FcRn 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
neonatal Fc Receptor (FcRn) (AA 24-297) protein (His tag)FcRn 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
neonatal Fc Receptor (FcRn) (AA 22-297) protein (His tag)FcRn 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
neonatal Fc Receptor (FcRn) (AA 24-297) protein (His-Avi Tag,Biotin)FcRn 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
neonatal Fc Receptor (FcRn) (AA 24-297) protein (His-Avi Tag)FcRn 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
neonatal Fc Receptor (FcRn) (AA 51-160) protein (GST tag)FcRn 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
neonatal Fc Receptor (FcRn) (AA 24-297) (Active) protein (His tag,Strep Tag)FcRn 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
neonatal Fc Receptor (FcRn) (AA 22-297) protein (His tag,Strep Tag)FcRn 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
neonatal Fc Receptor (FcRn) (AA 24-297) (Active) protein (His tag,Strep Tag,AVI tag,Biotin)FcRn 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
neonatal Fc Receptor (FcRn) (AA 22-297) protein (His tag)FcRn 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 85 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).
: "Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18754-18763, (2020) (PubMed).
: "Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody." in: The Journal of biological chemistry, Vol. 292, Issue 42, pp. 17449-17460, (2017) (PubMed).
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: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).
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- 抗原
- FcRn (neonatal Fc Receptor (FcRn))
- 别名
- FcRn (FcRn 产品)
- 背景
- FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
- 分子量
- 32.3 kDa (FCGRT), 13.1 kDa (B2M)
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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