IL1RN Protein (AA 26-177)
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北京 101111
Quick Overview for IL1RN Protein (AA 26-177) (ABIN2017978)
抗原
See all IL1RN 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 26-177
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产品特性
- ED50 < 0.1 μg /mL, measured in a neutralization assay using D10S cells in the presence of 50pg/mL Human IL-1a.
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内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 1 Receptor Antagonist (IL1RN) (AA 1-159) protein (GST tag)
IL1RN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 1 Receptor Antagonist (IL1RN) (AA 25-178) protein (His tag)IL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1 Receptor Antagonist (IL1RN) proteinIL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 1 Receptor Antagonist (IL1RN) (AA 18-332) protein (Fc Tag)IL1RN 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant human IL-1 Receptor Antagonist remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-1 Receptor Antagonist should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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有效期
- 6 months
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- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
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别名
- IL-1 Receptor Antagonist
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背景
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IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Synonyms: IL-1RA, ICIL-1RA, IRAP, IL-1RN -
分子量
- 18-23 kDa, observed by reducing SDS-PAGE.
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UniProt
- P18510
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途径
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
抗原
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