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Growth Hormone 1 Protein (GH1) (AA 27-217)

Name: Growth Hormone 1 Protein (GH1) (AA 27-217)
Brand: antibodies-online
SKU: ABIN2017922
Availability: OutOfStock

GH1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active

(3 references)

产品编号 ABIN2017922

发货至: 中国

Datasheet as PDF

抗原 See all Growth Hormone 1 (GH1) 蛋白

Growth Hormone 1 (GH1)

蛋白类型

Recombinant

生物活性

Active

产品特性

AA 27-217
宿主
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资源
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大肠杆菌（E. Coli）

产品特性

ED50 < 0.5 ng/mL, measured by a cell proliferation assay using Nb2-11 Cells, corresponding to a specific activity of > 2.0x 10^6 units/mg.

纯度

> 95 % by SDS-PAGE and HPLC analyses.

内毒素水平

< 0.2 EU/μg, determined by LAL method.

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Growth Hormone 1 (GH1) (AA 27-216) protein (His tag)
Crystallography grade GH1 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

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GH1 宿主: 人宿主: CHO Cells Recombinant SDS, Func Active

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限制

仅限研究用
状态

Lyophilized

溶解方式

Reconstituted in ddH2O at 100 μg/mL.

缓冲液

Lyophilized after extensive dialysis against PBS.

储存条件

-80 °C

储存方法

Lyophilized recombinant human Growth Hormone (rhGH) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhGH should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

有效期

6 months
Basu, Nahar, Kulkarni, Kerekes, Sattler, Hall, Neggers, Holub, Kopchick: "A novel peptide antagonist of the human growth hormone receptor." in: The Journal of biological chemistry, pp. 100588, (2021) (PubMed).

Qian, Basu, Mathes, Arnett, Duran-Ortiz, Funk, Brittain, Kulkarni, Terry, Davis, Singerman, Henry, List, Berryman, Kopchick: "Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo." in: Cancers, Vol. 12, Issue 12, (2020) (PubMed).

Basu, Baumgaertel, Wu, Kopchick: "Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps." in: Hormones & cancer, Vol. 8, Issue 3, pp. 143-156, (2018) (PubMed).
抗原

Growth Hormone 1 (GH1)

别名

Growth Hormone (GH) (GH1 产品)

别名

GH Protein, GH-N Protein, GHN Protein, IGHD1B Protein, hGH-N Protein, Gh1 Protein, GH1 Protein, gh Protein, Gh Protein, GH2 Protein, RNGHGP Protein, ghl Protein, gh-n Protein, ghn Protein, ighd1b Protein, gh1 Protein, ghb-A Protein, GHI Protein, GHB3 Protein, growth hormone 1 Protein, growth hormone Protein, somatotropin-like Protein, somatotropin Protein, growth hormone prepeptide Protein, growth hormone 1 L homeolog Protein, growth hormone 1 S homeolog Protein, Somatotropin-1 Protein, GH1 Protein, Gh Protein, GH Protein, LOC100305005 Protein, Gh1 Protein, LOC100534452 Protein, LOC100232594 Protein, LOC100303681 Protein, gh1 Protein, LOC100356068 Protein, LOC100136588 Protein, gh1.L Protein, gh1.S Protein, LOC109081196 Protein

背景

Growth Hormone (GH) is a member of the somatotropin/prolactin family which play an important role in growth control. The human GH cDNA encodes a 217 amino acid (aa), and the first 26 aa is a signal peptide. By alternative splicing, at least four isoforms of GH have been identified. The major role of GH in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts, and also stimulates amino acid uptake and protein synthesis in muscle and other tissues.Recombinant human Growth Hormone (rhGH) produced in E. coli is a single non-glycosylated polypeptide chain containing 191 amino acids. A fully biologically active molecule, rhGH has a molecular mass of 22.1 kDa analyzed by reducing SDS-PAGE.
Synonyms: GH1, GH, GHN, GH-N, hGH-N,Pituitary growth hormone, Growth hormone 1, Somatotropin

分子量

22.1 kDa, observed by reducing SDS-PAGE.

UniProt

P01241

途径

NF-kappaB Signaling, JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process