FGF23 蛋白
Quick Overview for FGF23 蛋白 (ABIN2017821)
抗原
See all FGF23 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI
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产品特性
- Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/mL, corresponding to a specific activity of > 2.0 x 10^3 IU/mg in the presence of 0.3 μg/mL of rMuKlotho and 10 μg/mL of heparin.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU/μg of rHuFGF-23 as determined by LAL method.
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Fibroblast Growth Factor 23 (FGF23) (AA 25-251) (Active) protein (His tag)
FGF23 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） > 90 % AcA, CC Active
Fibroblast Growth Factor 23 (FGF23) (AA 25-251) protein (His tag)FGF23 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibroblast Growth Factor 23 (FGF23) (AA 1-251) protein (GST tag)FGF23 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor 23 (FGF23) (AA 25-251), (full length) protein (His tag)FGF23 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
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缓冲液
- Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
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- FGF23 (Fibroblast Growth Factor 23 (FGF23))
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别名
- Fibroblast Growth Factor-23 (FGF-23)
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背景
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Fibroblast growth factor-23 (FGF-23) belongs to the large FGF family which has at least 23 members. All FGF family members are heparin binding growth factors with a core 120 amino acid (a.a.) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. FGF-23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressing circulating phosphate levels. FGF-23 interaction with renal proximal tubular epithelium decreases the renal resorption of phosphate by down regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate.
Synonyms: FGF-23 Human, -
分子量
- 25.3 kDa, a single non-glycosylated polypeptide chain containing 227 amino acids.
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion
抗原
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