VEGFR2/CD309 Protein (glycosylated, Monomer, Soluble)
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- 抗原 See all VEGFR2/CD309 (VEGFR2) 蛋白
- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- glycosylated, Monomer, Soluble
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宿主
- 人
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资源
- Insect Cells
- 原理
- VEGFR-2/KDR (D7), soluble
- 序列
- ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDL DWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTG AYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT ENKNKTVVIP CLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPS YMISYAGMVF CEAKINDESY QSIMYIVVVV GYRIYDVVLS PSHGIELSVG EKLVLNCTAR TELNVGIDFN WEYPSSKHQH KKLVNRDLKT QSGSEMKKFL STLTIDGVTR SDQGLYTCAA SSGLMTKKNS TFVRVHEKPF VAFGSGMESL VEATVGERVR IPAKYLGYPP PEIKWYKNGI PLESNHTIKA GHVLTIMEVS ERDTGNYTVI LTNPISKEKQ SHVVSLVVYV PPQIGEKSLI SPVDSYQYGT TQTLTCTVYA IPPPHHIHWY WQLEEECANE PSQAVSVTNP YPCEEWRSVE DFQGGNKIEV NKNQFALIEG KNKTVSTLVI QAANVSALYK CEAVNKVGRG ERVISFHVTR GPEITLQPDM QPTEQESVSL WCTADRSTFE NLTWYKLGPQ PLPIHVGELP TPVCKNLDTL WKLNATMFSN STNDILIMEL KNASLQDQGD YVCLAQDRKT KKRHCVVRQL TVLERVAPTI TGNLENQTTS IGESIEVSCT ASGNPPPQIM WFKDNETLVE DSGIVLKDGN RNLTIRRVRK EDEGLYTCQA CSVLGCAKVE AFFIIEGA
- 特异性
- Chromosomal location:4q11-q12
- 产品特性
- Length (aa):738
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product VEGFR2 蛋白
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VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag,Biotin)
VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His tag)VEGFR2 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (mFc Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (mFc Tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-762) protein (His tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (Fc Tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag,AVI tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (hIgG-His-tag)VEGFR2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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- 应用备注
- Measured by its ability to inhibit the VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells.
- 说明
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Soluble Receptors
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- The lyophilized human sKDR is soluble in water and most aqueous buffers, it should be reconstituted in water or PBS to a concentration of not lower than 100 μg/mL.
- 缓冲液
- 25 mM MES, 100 mM NaCl, pH 5.5
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- The material is stable for greater than six months at -20° C to -70° C. After the first thawing it is recommended to aliquote the material, because repeated freeze-thaw cycles will decrease the activity. Store at 4°C not longer than 2 days. Avoid repeated freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
- 别名
- VEGFR-2/KDR (VEGFR2 产品)
- 背景
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Recombinant Human soluble Endothelial Growth Factor Receptor-2 (sKDR(D7)) is produced as a non-chimeric protein in a monomeric form. The soluble receptor protein consists of all 7 extracellular domains, which contain all the information necessary for high affinity ligand binding. The receptor monomers have a mass of approximately 116 kDa.Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
Synonyms: soluble vascular endothelial growth factor receptor-2 , soluble CD309, soluble VEGF receptor-2, sKDR - 分子量
- 116.0 kDa
- 基因ID
- 3791
- NCBI登录号
- NM_002253, NP_002244
- UniProt
- P35968
- 途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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