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VEGFR2/CD309 Protein (glycosylated, Monomer, Soluble)

Name: VEGFR2/CD309 Protein (glycosylated, Monomer, Soluble)
SKU: ABIN1589573
Availability: OutOfStock

This Recombinant VEGFR2/CD309 protein is expressed in Insect Cells.

产品编号 ABIN1589573

发货至: 中国

Quick Overview for VEGFR2/CD309 Protein (glycosylated, Monomer, Soluble) (ABIN1589573)

抗原

See all VEGFR2/CD309 (VEGFR2) 蛋白

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

Insect Cells

纯度

> 95 % by SDS-PAGE

Discover our top product VEGFR2 蛋白

产品特性

glycosylated, Monomer, Soluble

原理

VEGFR-2/KDR (D7), soluble

序列

ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDL DWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTG AYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT ENKNKTVVIP CLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPS YMISYAGMVF CEAKINDESY QSIMYIVVVV GYRIYDVVLS PSHGIELSVG EKLVLNCTAR TELNVGIDFN WEYPSSKHQH KKLVNRDLKT QSGSEMKKFL STLTIDGVTR SDQGLYTCAA SSGLMTKKNS TFVRVHEKPF VAFGSGMESL VEATVGERVR IPAKYLGYPP PEIKWYKNGI PLESNHTIKA GHVLTIMEVS ERDTGNYTVI LTNPISKEKQ SHVVSLVVYV PPQIGEKSLI SPVDSYQYGT TQTLTCTVYA IPPPHHIHWY WQLEEECANE PSQAVSVTNP YPCEEWRSVE DFQGGNKIEV NKNQFALIEG KNKTVSTLVI QAANVSALYK CEAVNKVGRG ERVISFHVTR GPEITLQPDM QPTEQESVSL WCTADRSTFE NLTWYKLGPQ PLPIHVGELP TPVCKNLDTL WKLNATMFSN STNDILIMEL KNASLQDQGD YVCLAQDRKT KKRHCVVRQL TVLERVAPTI TGNLENQTTS IGESIEVSCT ASGNPPPQIM WFKDNETLVE DSGIVLKDGN RNLTIRRVRK EDEGLYTCQA CSVLGCAKVE AFFIIEGA

特异性

Chromosomal location:4q11-q12

产品特性

Length (aa):738
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VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag)
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应用备注

Measured by its ability to inhibit the VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells.

说明

Soluble Receptors

限制

仅限研究用
状态

Lyophilized

溶解方式

The lyophilized human sKDR is soluble in water and most aqueous buffers, it should be reconstituted in water or PBS to a concentration of not lower than 100 μg/mL.

缓冲液

25 mM MES, 100 mM NaCl, pH 5.5

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

4 °C,-20 °C,-80 °C

储存方法

The material is stable for greater than six months at -20° C to -70° C. After the first thawing it is recommended to aliquote the material, because repeated freeze-thaw cycles will decrease the activity. Store at 4°C not longer than 2 days. Avoid repeated freeze-thaw cycles.

有效期

6 months
抗原

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

别名

VEGFR-2/KDR

背景

Recombinant Human soluble Endothelial Growth Factor Receptor-2 (sKDR(D7)) is produced as a non-chimeric protein in a monomeric form. The soluble receptor protein consists of all 7 extracellular domains, which contain all the information necessary for high affinity ligand binding. The receptor monomers have a mass of approximately 116 kDa.Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
Synonyms: soluble vascular endothelial growth factor receptor-2 , soluble CD309, soluble VEGF receptor-2, sKDR

分子量

116.0 kDa

基因ID

3791

NCBI登录号

NM_002253, NP_002244

UniProt

P35968

途径

RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling